RESUMO
La prevalencia del asma ha aumentado en las últimas décadas, especialmente en los países desarrollados, por motivos no bien esclarecidos. En los últimos años se ha observado una asociación entre el uso de paracetamol en distintas etapas de la vida, incluyendo la gestación y la infancia, y la prevalencia de asma. El carácter observacional de los estudios publicados no permite establecer una relación causal. Sería necesario realizar ensayos clínicos para comprobar la naturaleza de la asociación, que podría deberse a la presencia de diversos factores de confusión. Las sociedades pediátricas españolas firmantes de este artículo consideran que los datos disponibles hasta la fecha no son suficientes para desaconsejar el uso de paracetamol durante la gestación ni en niños asmáticos o con riesgo de asma (AU)
Asthma prevalence has increased over the last few decades, especially in developed countries, and possibly due to different reasons. An association between paracetamol use or exposure at different periods of life, including gestation and childhood, and asthma prevalence has been observed in the last few years. Causality can not be established from observational reports, due to the arguable presence of many confounding factors and biases. Randomised trials are needed to elucidate the nature of this association. The Spanish Paediatric societies subscribing to this paper consider that current evidence is insufficient to discourage the use of paracetamol during gestation or in children with or at risk of asthma (AU)
Assuntos
Humanos , Masculino , Feminino , Criança , Acetaminofen/efeitos adversos , Asma/induzido quimicamente , Fatores de Risco , Exposição MaternaRESUMO
Asthma prevalence has increased over the last few decades, especially in developed countries, and possibly due to different reasons. An association between paracetamol use or exposure at different periods of life, including gestation and childhood, and asthma prevalence has been observed in the last few years. Causality can not be established from observational reports, due to the arguable presence of many confounding factors and biases. Randomised trials are needed to elucidate the nature of this association. The Spanish Paediatric societies subscribing to this paper consider that current evidence is insufficient to discourage the use of paracetamol during gestation or in children with or at risk of asthma.
Assuntos
Acetaminofen/efeitos adversos , Analgésicos não Narcóticos/efeitos adversos , Antipiréticos/efeitos adversos , Asma/induzido quimicamente , Asma/prevenção & controle , Acetaminofen/uso terapêutico , Analgésicos não Narcóticos/uso terapêutico , Antipiréticos/uso terapêutico , Criança , HumanosAssuntos
Eritema/etiologia , Hipersensibilidade Alimentar/diagnóstico , Alimentos/efeitos adversos , Sudorese Gustativa/complicações , Criança , Pré-Escolar , Diagnóstico Diferencial , Eritema/diagnóstico , Face , Feminino , Hipersensibilidade Alimentar/complicações , Hipersensibilidade Alimentar/imunologia , Humanos , Lactente , Masculino , Sudorese Gustativa/diagnóstico , Sudorese Gustativa/imunologiaRESUMO
No disponible
Assuntos
Humanos , Masculino , Feminino , Lactente , Asma/epidemiologia , Sons Respiratórios/classificação , Infecções Respiratórias/complicações , Viroses/complicações , Hipersensibilidade Imediata/epidemiologia , FenótipoRESUMO
No disponible
Assuntos
Humanos , Masculino , Feminino , Criança , /métodos , Asma/diagnóstico , Espirometria/métodos , Pneumopatias/fisiopatologia , Valores de ReferênciaRESUMO
No disponible
Assuntos
Humanos , Predisposição Genética para Doença , Asma/genética , Marcadores Genéticos , Fatores de Risco , Genômica/tendências , Epigênese Genética , Broncodilatadores/uso terapêuticoRESUMO
Objetivo: Resaltar la peligrosidad de la posible ingesta accidental de chicles de nicotina en niños, debido a su forma de presentación, similar a la de sus golosinas. Material y Métodos: Estudio observacional retrospectivo de cuatro casos de ingesta accidental de 1-2 chicles de nicotina de 2 mg en niñas, registrados en el Hospital General de Segovia durante el año 2007 con edades comprendidas entre los 4 y los 7 años. Resultados: En los cuatro casos apareció sintomatología tras la ingesta del chicle, que ocurrió 20-30 minutos después de estar masticándolo. Los síntomas predominantes, en el 75% de los casos fueron náuseas, vómitos y mareo. En dos casos, 30 minutos tras la ingesta, se administró en el Servicio de Urgencias carbón activado, a los otros dos por haber pasado 4 horas tras la ingesta no se les administró. Tras permanecer 12 horas en observación y estando asintomáticas fueron dadas de alta. Discusión: La ingesta accidental de chicles de nicotina puede producir importantes efectos adversos, los cuales aparecen más rápidamente en niños que en adultos. Debe considerarse como primera medida, y más aún en la primera hora tras la ingesta la administración de carbón activado. Puesto que los niños los pueden confundir fácilmente e ingerir de forma accidental, debería tenerse en cuenta la modificación en su forma de presentación por parte de la industria farmacéutica, así como, un mayor cuidado por parte de los padres para evitar que los niños los tengan a su alcance y los ingieran (AU)
Objective: Stress the dangerousness of the possible accidental intake of nicotine gums in children due to their presentation form that is similar to that of sweets. Material and Methods: Observational, retrospective study of 4 cases in girls whose ages ranged from 4 to 7 years of accident intake of 1-2 nicotine gums of 2 mg recorded in the Hospital General of Segovia during the year 2007.Results: In the four cases, symptoms appeared after the intake of the gum, this occurring 20-30 minutes after they were chewed. The predominant symptoms in 75% of the cases were nausea, vomiting and dizziness. At 30 minutes of the intake, two cases were administered activated carbon in the Emergency Department, and there maining two were not administered it because 4 hours had passed since the intake. After remaining in observation for 12 hours and being asymptomatic, they were discharged. Discussion: Accidental intake of nicotine gum may cause important adverse effects, these appearing faster in children than in adults. Administration of activated carbon should be considered as the first measure, and even more so during the first hours after its intake. Since children can easily confuse it and accidentally consume it, the pharmaceutical industry should consider changing its presentation form. Furthermore, parents should be more careful so as to prevent their children from having access to it and consuming it (AU)
